One year at the SAG Awards, somebody practically knocked me over, and it was Helen Mirren. She was like, 'Oh my God - is it really you? I'm your biggest fan.' I was like, 'Wait, aren't you supposed to be home reading Shakespeare or something?'

I married the reigning mustache champion.

There's kind of a double standard: if a musician decides they want to act, everybody falls over themselves. But if you're an actor and you have a band, everyone's, 'Ugh, disgusting! It's a vanity project.'

Nobody knew if the pilot would even get picked up because it had two gay lead characters, which has never happened before. And now every show has at least two gay characters, if not many more.

You should definitely stay true to your own style.

Nick gets carsick if he's not driving - plus, he's basically a walking atlas. He can drive around any city without a map, which works out fine for me because I just become our entertainment director and pick out which audio book we'll listen to next.

We had a gay marriage on 'Will & Grace' in 2000, 2001. And I was like, 'Gay marriage?' I mean, it was just really early.

Speaking theoretically, in a completely made-up world where 'Will & Grace' is coming back to NBC for 10 episodes - just in that made-up world - it couldn't be a better time. I think more so now than even when we started! And who would have ever - I mean, it's heinous that it's because Donald Trump is the president-elect.

If we're ever seen having a public spat in a coffee shop, I think the concept of romance will die.

A lot of young people think it all comes to a screeching halt once you're 32. But it really doesn't.

At first, people were like, 'I've discovered something - you guys are married!' I was like, 'Yeah, that's not a secret. We've been married now already for many years.'

Nick's just from this very Norman Rockwell-ish family. They're very 'American Gothic,' and his parents are so kind, and they're not brash people; they're very soft spoken, salt of the earth.

Nick can get up on stage and just wing it, whereas I would have to be taken to a mental institution.

I get deep into the creative aspect, and Nick is the people person.

Karen will never die. Max Mutchnick, one of the creators of the show, has always maintained that Karen is a bat who balls up and hangs from a rafter and sleeps during the day and that she'll live forever.

Nick hasn't seen me naked - I'm not a person who's constantly flinging my clothes aside and strutting about.

I always thought, 'Oh, Cher seems so cool. If I ever met her, I know we'd be best friends.'

All the writers on our show went in and got in the bed and took a picture in Cher's bed, even though she was never in it.

I can understand everybody associates me with Karen, but beyond that, I think after time passes and a few years go by, that sort of becomes a non-issue. That character is far - I mean really, all the characters I've played are pretty far away from what I'm really like.

I love creating new characters that are whatever they are.

Multi-camera's fun because you have the immediacy of the audience and just being able to tell the story more or less straight through. The thing I like about single-camera is that you have the luxury of shooting a lot of different options.

You can really shoot things you think might work on camera one way, then you can try it that way, and then if you think it could also work another way, you have that luxury of shooting a bunch of different steps, and then they can decide in editing what works the best.

I'm a big hit with guards at security. They're the center of my fan base, the airport security guards.

My mom was extremely supportive of me, but it could err on the side of... I mean, there's supportive, and then there's just full-on over-hovering.

I had a lot of friends for a long time who were gay, and I didn't even realize it for awhile. Even in my mid- to late 20s, I was still pretty naive about it.

I certainly have gay friends, but I don't remember thinking, 'Oh my God, I have this friend, and they're gay, and that's so cool.' I mean, I was very naive until I got to a certain age.

You can't really be super conservative and continue to keep your audience, but at least the audience that we attract comes with a certain level of naughtiness.

I don't know other couples that work together a fraction as much as Nick and I do. We met in a play, and we've done TV and movies, and we just did 'Annapurna,' our off-Broadway show, and we've done theater together several times, so it's just a little bit of everything.

I think theater is more about living and breathing, versus TV, which can vary.

I kind of connected the dots, like, 'Oh, we're just saying stuff. We're just saying things that make sense, so let's just say them like you say them in real life.' It was my first and one of my only acting lessons 'cause I never really studied acting.

It's funny when you follow your own sort of bliss, then other people tend to respond in kind, meaning audiences. It's really weird how that works, but it does seem to apply to 'Nancy & Beth' especially.

I like to work. I mean, part of it for me is that I was a struggling actor, could barely pay my rent, until I was almost 40.

I think a lot of actors, maybe who have been on a hit show and been lucky enough to get successful, might say 'no' more than I do. And maybe that's good, maybe that's smart. I don't know.

A lot of people are saying it's an inspiration to see a couple who are in love and getting a kick out of each other.

Now, it's weird not to have gay characters on a show.

I'm from Oklahoma, and Nick's from a small town in Illinois.

Nick was cast first in both 'Smashed' and 'Kings.'

My mom is elderly, and she's not doing too well, and I've literally never told her about 'Childrens Hospital,' because I fear that if she ever sees it, it will be like the coup de grace.

I love Chicago - absolutely love Chicago. I mean, I'd much rather go to Chicago and do a play or a musical than New York, honestly. Because just probably for reasons that are obvious to you. It's just a little bit - it's a nicer, easier city.

I get offered stuff that I don't really want to do, so hopefully, I'm just kind of waiting for the right thing.

I'd just like to retire quietly with dignity, secure in the knowledge that no more comedies will ever be made now that I'm gone.