Are the atoms of the dextroacid (tartaric) grouped in the spirals of a right-hand helix or situated at the angles of an irregular tetrahedron, or arranged in such or such particular unsymmetrical fashion? We are unable to reply to these questions. But there can be no reason for doubting that the grouping of the atoms has an unsymmetrical arrangement with a non-superimposable image. It is not less certain that the atoms of the laevo-acid realize precisely an unsymmetrical arrangement of the inverse of the above.
Great problems are now being handled, keeping every thinking man in suspense; the unity or multiplicity of human races; the creation of man 1,000 years or 1,000 centuries ago; the fixity of species, or the slow and progressive transformation of one species into another; the eternity of matter; the idea of a God unnecessary: such are some of the questions that humanity discusses nowadays.
I propose to provide proof... that just as always an alcoholic ferment, the yeast of beer, is found where sugar is converted into alcohol and carbonic acid, so always a special ferment, a lactic yeast, is found where sugar is transformed into lactic acid. And, furthermore, when any plastic nitrogenated substance is able to transform sugar into that acid, the reason is that it is a suitable nutrient for the growth of the [lactic] ferment.
No, there is now no circumstance known in which it can be affirmed that microscopic beings came into the world without germs, without parents similar to themselves. Those who affirm it have been duped by illusions, by ill-conducted experiments, spoilt by errors that they either did not perceive or did not know how to avoid.
Without theory, practice is but routine born of habit. Theory alone can bring forth and develop the spirit of invention. ... [Do not] share the opinion of those narrow minds who disdain everything in science which has not an immediate application. ... A theoretical discovery has but the merit of its existence: it awakens hope, and that is all. But let it be cultivated, let it grow, and you will see what it will become.
These microscopic organisms form an entire world composed of species, families and varieties whose history, which has barely begun to be written, is already fertile in prospects and findings of the highest importance. The names of these organisms are very numerous and will have to be defined and in part discarded. The word microbe which has the advantage of being shorter and carrying a more general meaning, and of having been approved by my illustrious friend, M. Littré, the most competent linguist in France, is one we will adopt.
To demonstrate experimentally that a microscopic organism actually is the cause of a disease and the agent of contagion, I know no other way, in the present state of Science, than to subject the microbe (the new and happy term introduced by M. Sédillot) to the method of cultivation out of the body.
Virulence appears in a new light which cannot but be alarming to humanity; unless nature, in her evolution down the ages (an evolution which, as we now know, has been going on for millions, nay, hundreds of millions of years), has finally exhausted all the possibilities of producing virulent or contagious diseases - which does not seem very likely.
Preconceived ideas are like searchlights which illumine the path of the experimenter and serve him as a guide to interrogate nature. They become a danger only if he transforms them into fixed ideas-this is why I should like to see these profound words inscribed on the threshold of all the temples of science: 'The greatest derangement of the mind is to believe in something because one wishes it to be so.'
When you believe you have found an important scientific fact, and are feverishly curious to publish it, constrain yourself for days, weeks, years sometimes, fight yourself, try and ruin your own experiments, and only proclaim your discovery after having exhausted all contrary hypotheses. But when, after so many efforts you have at last arrived at a certainty, your joy is one of the greatest which can be felt by a human soul.