Basically, everything I try to do is to present an alternative to what somebody else is doing.

I've loved science fiction ever since I was a little kid, mainly from looking at the covers of science-fiction magazines and books, and I've read quite extensively as an adult.

I don't have to be careful, I've got a gun.

God often gives nuts to toothless people.

It's just hard not to listen to TV: it's spent so much more time raising us than parents have.

I don't know why I did it, I don't know why I enjoyed it, and I don't know why I will do it again.

I'm a writer who just happens to draw.

I was always frightened by taverns. They just seemed like very unpleasant places to go.

Cartooning is for people who can't quite draw and can't quite write. You combine the two half-talents and come up with a career.

I like the 'Simpsons' pinball machines. Those are pretty great.

I think in daily newspapers, the way comic strips are treated, it's as if newspaper publishers are going out of their way to kill the medium.

I judge my life by how miserable it used to be. If I could pay my rent, I was deliriously happy. Now I'm deliriously happy all the time.

Oftentimes, what seems to be a street lunatic charging at me spouting gibberish turns out to be a devoted 'Simpsons' fan quoting their favorite line.

I have less to do with 'The Simpsons' every season, but I stick my nose in here and there. Basically, it's just trying to keep the characters consistent and making sure the show has a soul.

With animation, because you can draw anything and do anything and have the characters do whatever you want, the tendency is to be very loose with the boundaries and the rules.

I always say that 'Futurama' is real, and 'The Simpsons' is fiction.

One of the great things about the Internet is that you can read what everybody has to say about everything. It is fascinating to me, the critiques about humor by people who have no sense of humor.

The really great thing about having two TV shows going on at the same time is that I can go to one and say that I have to go and visit the other, and then I can just go home, and they don't know.

'Adult Swim' on the Cartoon Network is unbelievable. And 'South Park' continues to do great stuff. And 'Family Guy' and the various other Seth MacFarlane projects are amazing.

I think when 'The Simpsons' first came on, there was an uproar. People got used to it. They realized the show's really funny, it's got a heart, so I think it's pretty safe.

I gave away 'Life in Hell' when it was a little 'zine, and sold it at record stores for $1, and I knew from the time that I first did it that I would continue to do it, because it was fun.

The tendency in comedy is to have a character who's stupid get more stupid, because you're trying to top yourself and not just repeat.

Science fiction and comedy are generally a pretty bumpy mix.

As astute followers of 'Life in Hell' will notice, Akbar and Jeff wear the same striped T-shirt as Charlie Brown. 'Peanuts' was very important to me.